Immunogen sequence: QSDHAQDAGE TAAGGGERPS GQDLRATMQR KGISSSMSFD EDEEDEEENS SSSSQLNSNT RPSSATSRKS VREAASAPSP TAPEQPVDVE VQDLEEFALR PAPQGITIKC RITRDKK
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 92%.
This gene encodes a member of the Tubby family of bipartite transcription factors. The encoded protein may play a role in obesity and sensorineural degradation. The crystal structure has been determined for a similar protein in mouse, and it functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis. Two transcript variants encoding distinct isoforms have been identified for this gene.
Protein Aliases: tubby homolog; tubby homologue; Tubby protein homolog
Gene Aliases: rd5; RDOB; TUB
UniProt ID: (Human) P50607
Entrez Gene ID: (Human) 7275