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Invitrogen
TUSC2 Polyclonal Antibody
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Product Details
PA5-101075
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TUSC2(Accession O75896), corresponding to amino acid residues F52-D102.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TUSC2.
Target Information
TUSC2 (tumor suppressor candidate 2), also known as FUS1, LGCC or PDAP2, is a 110 amino acid protein that is expressed at high levels in kidney, pancreas, lung, heart and skeletal muscle where it is thought to function as a tumor suppressor. More specifically, TUSC2 inhibits invasive colony formation by inducing G1 cell cycle arrest and ultimately causing apoptosis, thereby preventing tumor growth. The gene encoding TUSC2 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fus-1 protein; Fusion 1 protein; lung cancer candidiate, FUS; PDGFA associated protein 2; PDGFA-associated protein 2; Tumor suppressor candidate 2; TUSC 2; unnamed protein product
Gene Aliases: 1190001E22Rik; AA407686; C3orf11; FUS1; LGCC; PAP; PDAP2; TUSC2
UniProt ID: (Human) O75896, (Mouse) Q9WVF8
Entrez Gene ID: (Human) 11334, (Mouse) 80385
natural killer cell differentiation
phagocytosis
inflammatory response
negative regulation of interleukin-17 production
positive regulation of interleukin-10 production
cell maturation
defense response to Gram-negative bacterium
regulation of mitochondrial membrane potential
neutrophil mediated killing of gram-negative bacterium
regulation of reactive oxygen species metabolic process
interleukin-15 production
response to defense-related host reactive oxygen species production
chemokine (C-C motif) ligand 5 production
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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