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Proteintech
TUSC4 Polyclonal Antibody
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Product Details
10157-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TUSC4 Fusion Protein Ag0210 (1-270 aa encoded by BC002791)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GCRIECIFF SEFHPTLGPK ITYQVPEDFI SRELFDTVQV YIITKPELQN KLITVTAMEK KLIGCPVCIE HKKYSRNALL FNLGFVCDAQ AKTCALEPIV KKLAGYLTTL ELESSFVSME ESKQKLVPIM TILLEELNAS GRCTLPIDES NTIHLKVIEQ RPDPPVAQEY DVPVFTKDKE DFFNSQWDLT TQQILPYIDG FRHIQKISAE ADVELNLVRI AIQNLLYYGV VTLVSILQYS NVYCPTPKVQ DLVDDKSLQE ACLSYVTKQG H (1-270 aa encoded by BC002791)
Target Information
NPRL2, also known as TUSC4 (tumor suppressor candidate 4), is a 380 amino acid protein that contains a bipartite nuclear localization signal and a granulin protein-binding domain. It is highly expressed in skeletal muscle, followed by brain, liver and pancreas, with lower expression in lung, kidney, placenta and heart. NPRL2 is also expressed in most lung cancer cell lines and may be involved in tumor suppression. NPRL2 may play a role in mismatch repair, cell cycle checkpoint signaling and activation of apoptotic pathways. It may also enhance the therapeutic efficacy of chemotherapy drugs such as cis-platin by resensitizing patients resistant to cisplatin treatment. The gene encoding NPRL2 is conserved between species and is expressed as two isoforms due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2810446G01Rik; G21 protein; GATOR complex protein NPRL2; GATOR1 complex protein NPRL2; Gene 21 protein; homologous to yeast nitrogen permease (candidate tumor suppressor); mutant NPRL2; nitrogen permase homolog; Nitrogen permease regulator 2-like protein; NPR 2L; NPR L2; NPR like 2; NPR2 like; NPR2-like protein; NPRL 2; similar to yeast NPR2 nitrogen permease regulator; Tumor suppressor candidate 4; TUSC 4; TUSC 4 protein; TUSC4; TUSC4 protein; unnamed protein product
Gene Aliases: 2810446G01Rik; FFEVF2; G21; NPR2; NPR2L; NPRL2; TUSC4
UniProt ID: (Human) Q8WTW4, (Mouse) Q9WUE4
Entrez Gene ID: (Human) 10641, (Mouse) 56032, (Rat) 363138
cytoplasmic translation
positive regulation of autophagy
cellular response to nutrient levels
negative regulation of kinase activity
cellular response to amino acid starvation
TORC1 signaling
negative regulation of translational initiation
positive regulation of translational initiation
cellular response to methionine
protein localization to lysosome
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
protein phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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