Proteintech

TWF1 Polyclonal Antibody

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Antibody Testing Data (5)

TWF1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 5

TWF1 Antibody (11732-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using (Product # 11732-1-AP) (TWF1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

11732-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

TWF1 Fusion Protein Ag2332 (1-343 aa encoded by BC022344)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ASEDVKEIF ARARNGKYRL LKISIENEQL VIGSYSQPSD SWDKDYDSFV LPLLEDKQPC YILFRLDSQN AQGYEWIFIA WSPDHSHVRQ KMLYAATRAT LKKEFGGGHI KDEVFGTVKE DVSLHGYKKY LLSQSSPAPL TAAEEELRQI KINEVQTDVG VDTKHQTLQG VAFPISREAF QALEKLNNRQ LNYVQLEIDI KNEIIILANT TNTELKDLPK RIPKDSARYH FFLYKHSHEG DYLESIVFIY SMPGYTCSIR ERMLYSSCKS RLLEIVERQL QMDVIRKIEI DNGDELTADF LYEEVHPKQH AHKQSFAKPK GPAGKRGIRR LIRGPAETEA TTD (1-343 aa encoded by BC022344)

Target Information

This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Overexpression of TWF1 promotes lung adenocarcinoma progression and is associated with poor prognosis in cancer patients through the MMP1 signaling pathway.

Journal of thoracic disease

Zhai K,Jiang N,Wen JF,Zhang X,Liu T,Long KJ,Ke XX,Xu G,Chen C

Tue May 30 00:00:00 EDT 2023

Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway.

Biochemical and biophysical research communications

Li L,Liu L,Qu B,Li X,Gao X,Zhang M

Sat Oct 21 00:00:00 EDT 2017

Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway.

Biochemical and biophysical research communications

Li L,Liu L,Qu B,Li X,Gao X,Zhang M

Sat Oct 21 00:00:00 EDT 2017

Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway.

Biochemical and biophysical research communications

Li L,Liu L,Qu B,Li X,Gao X,Zhang M

Sat Oct 21 00:00:00 EDT 2017

Twinfilin 1 enhances milk bio-synthesis and proliferation of bovine mammary epithelial cells via the mTOR signaling pathway.

Biochemical and biophysical research communications

Li L,Liu L,Qu B,Li X,Gao X,Zhang M

Sat Oct 21 00:00:00 EDT 2017

Bioinformatics

Protein Aliases: A6 protein tyrosine kinase; actin monomer-binding protein; Protein A6; Protein tyrosine kinase 9; PTK9 protein tyrosine kinase 9; twinfilin actin-binding protein 1; twinfilin, actin-binding protein, homolog 1; Twinfilin-1

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Gene Aliases: A6; PTK9; TWF1; twinfilin

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UniProt ID: (Human) Q12792, (Rat) Q5RJR2, (Mouse) Q91YR1

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Entrez Gene ID: (Human) 5756, (Rat) 315265, (Mouse) 19230

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Function(s)

actin monomer binding protein tyrosine kinase activity ATP binding phosphatidylinositol-4,5-bisphosphate binding protein complex binding cadherin binding involved in cell-cell adhesion actin binding non-motor actin binding protein

Process(es)

peptidyl-tyrosine phosphorylation negative regulation of actin filament polymerization sequestering of actin monomers regulation of actin phosphorylation barbed-end actin filament capping cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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TWF1 Polyclonal Antibody

TWF1 Antibody (11732-1-AP) in IHC (P)

Product Details

11732-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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