Invitrogen

TWIST1 Polyclonal Antibody

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Protocols
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Product Details

PA5-120863

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein (or fragment)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914435

Product Specific Information

Positive test controls include: Rat heart. The target is usually found in the following locations: Nucleus.

Target Information

TWIST1 acts as a transcriptional regulator. It inhibits myogensis by sequestering E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. TWIST1 also represses proinflammatory cytokines such as TNFA and IL1B. TWIST also regulates cranial suture patterning and fusion and gene expression differentially depending on dimer composition. Mutations in the gene are implicated in Saethre-Chotzen syndrome, a disease characterized by coronal synostosis, brachycephaly, low front hairline, facial asymmetry, hypertelorism, broad halluces, and clinodactyly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B-HLH DNA binding protein; bHLHa38; charlie chaplin; Class A basic helix-loop-helix protein 38; H-twist; M-twist; p ACS3; Pluridigite; polydactyly EMS; Skam10Jus; twist basic helix-loop-helix transcription factor 1; twist gene homolog 1; twist homolog 1; TWIST homolog of drosophila; Twist-related protein 1

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Gene Aliases: AA960487; ACS3; BHLHA38; BPES2; BPES3; CRS; CRS1; CSO; M-Twist; Pde; pdt; SCS; Ska10; Ska; TWIST; TWIST1

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UniProt ID: (Human) Q15672, (Mouse) P26687

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Entrez Gene ID: (Human) 7291, (Mouse) 22160, (Rat) 85489

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding protein domain specific binding protein homodimerization activity bHLH transcription factor binding protein heterodimerization activity E-box binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein dimerization activity molecular_function basic helix-loop-helix transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter ossification osteoblast differentiation in utero embryonic development neuron migration neural tube closure aortic valve morphogenesis mitral valve morphogenesis endocardial cushion morphogenesis cardiac neural crest cell migration involved in outflow tract morphogenesis transcription, DNA-templated muscle organ development positive regulation of gene expression positive regulation of epithelial to mesenchymal transition negative regulation of phosphatidylinositol 3-kinase signaling regulation of bone mineralization positive regulation of fatty acid beta-oxidation negative regulation of tumor necrosis factor production positive regulation of tumor necrosis factor production negative regulation of histone phosphorylation negative regulation of histone acetylation embryonic forelimb morphogenesis embryonic hindlimb morphogenesis negative regulation of peroxisome proliferator activated receptor signaling pathway outer ear morphogenesis odontogenesis embryonic digit morphogenesis negative regulation of apoptotic process negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of DNA damage response, signal transduction by p53 class mediator negative regulation of osteoblast differentiation positive regulation of angiogenesis negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process negative regulation of skeletal muscle tissue development embryonic cranial skeleton morphogenesis positive regulation of epithelial cell proliferation palate development cranial suture morphogenesis embryonic camera-type eye formation eyelid development in camera-type eye cellular response to growth factor stimulus cellular response to hypoxia positive regulation of monocyte chemotactic protein-1 production positive regulation of DNA-templated transcription, initiation positive regulation of cell motility negative regulation of oxidative phosphorylation uncoupler activity positive regulation of transcription regulatory region DNA binding negative regulation of cellular senescence positive regulation of interleukin-6 secretion negative regulation of double-strand break repair cell proliferation involved in heart valve development positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation regulation of transcription, DNA-templated transcription from RNA polymerase II promoter multicellular organism development cell differentiation embryonic limb morphogenesis hindlimb morphogenesis negative regulation of molecular function negative regulation of cell differentiation negative regulation of striated muscle tissue development embryonic skeletal system morphogenesis cardiac neural crest cell development involved in outflow tract morphogenesis bone development
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