The MW of this protein is 45 kDa, and this antibody specifically recognizes the 45 kDa protein.
TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
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Protein Aliases: twisted gastrulation homolog 1; Twisted gastrulation protein homolog 1
Gene Aliases: 1810013J15Rik; 9030422N06Rik; AW552143; D17Ertd403e; PSEC0250; TSG; Twg; TWSG1