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Proteintech
TWSG1 Polyclonal Antibody
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Product Details
12327-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TWSG1 Fusion Protein Ag2983 (14-223 aa encoded by BC020490)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The MW of this protein is 45 kDa, and this antibody specifically recognizes the 45 kDa protein.
Immunogen sequence: LMFLTWLPE SLSCNKALCA SDVSKCLIQE LCQCRPGEGN CSCCKECMLC LGALWDECCD CVGMCNPRNY SDTPPTSKST VEELHEPIPS LFRALTEGDT QLNWNIVSFP VAEELSHHEN LVSFLETVNQ PHHQNVSVPS NNVHAPYSSD KEHMCTVVYF DDCMSIHQCK ISCESMGASK YRWFHNACCE CIGPECIDYG SKTVKCMNCM F (14-223 aa encoded by BC020490)
Target Information
TWSG1 may be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: twisted gastrulation homolog 1; Twisted gastrulation protein homolog 1
Gene Aliases: 1810013J15Rik; 9030422N06Rik; AW552143; D17Ertd403e; PSEC0250; TSG; Twg; TWSG1
UniProt ID: (Human) Q9GZX9, (Mouse) Q9EP52
Entrez Gene ID: (Human) 57045, (Mouse) 65960, (Rat) 363294
ossification
mesoderm formation
salivary gland morphogenesis
hemopoiesis
cell differentiation
BMP signaling pathway
positive regulation of BMP signaling pathway
negative regulation of BMP signaling pathway
forebrain development
camera-type eye development
negative regulation of osteoblast differentiation
multicellular organism development
embryo development
tissue development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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