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TXNDC3 Antibody (PA5-120532) in WB
Western blot analysis of TXNDC3 in extracts of various cell lines. Samples were incubated with TXNDC3 Polyclonal antibody (Product # PA5-120532) using a dilution of 1:3,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-120532
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 299-588 of human NME8 (NP_057700.3).
Conjugate
Form
Liquid
Concentration
3.59 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914104
Product Specific Information
Positive test controls include: U-87MG, SH-SY5Y, Jurkat.
Immunogen sequence: FMDAFFPDFK KMKSMKLEKT LALLRPNLFH ERKDDVLRII KDEDFKILEQ RQVVLSEKEA QALCKEYENE DYFNKLIENM TSGPSLALVL LRDNGLQYWK QLLGPRTVEE AIEYFPESLC AQFAMDSLPV NQLYGSDSLE TAEREIQHFF PLQSTLGLIK PHATSEQREQ ILKIVKEAGF DLTQVKKMFL TPEQIEKIYP KVTGKDFYKD LLEMLSVGPS MVMILTKWNA VAEWRRLMGP TDPEEAKLLS PDSIRAQFGI SKLKNIVHGA SNAYEAKEVV NRLFEDPEEN
Target Information
This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3'-5' exonuclease NME8; epididymis secretory protein Li 99; NM23-H8; NME/NM23 family member 8; sperm-specific thioredoxin 2; Spermatid-specific thioredoxin-2; Sptrx-2; thioredoxin domain containing 3 (spermatozoa); Thioredoxin domain-containing protein 3
Gene Aliases: 1700056P15Rik; CILD6; HEL-S-99; NM23-H8; NME8; Sptrx-2; SPTRX2; TXNDC3
UniProt ID: (Human) Q8N427, (Mouse) Q715T0
Entrez Gene ID: (Human) 51314, (Mouse) 73412
nucleoside diphosphate phosphorylation
GTP biosynthetic process
UTP biosynthetic process
CTP biosynthetic process
multicellular organism development
spermatogenesis
cell differentiation
sperm motility
cellular response to reactive oxygen species
cilium assembly
cell redox homeostasis
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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