Proteintech

TXNIP Polyclonal Antibody

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TXNIP Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human kidney tissue slide using 18243-1-AP ( TXNIP Antibody) at dilution of 1:200 (under 40x lens).

TXNIP Antibody in Western Blot (WB) — HL-60 cells were subjected to SDS PAGE followed by western blot with 18243-1-AP (TXNIP antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

18243-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 10 publications 10 publications
Immunohistochemistry (IHC)	-	View 3 publications 3 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-
Immunocytochemistry (ICC/IF)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse
Published species	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	TXNIP Fusion Protein Ag13009 (1-391 aa encoded by BC093702) View antigen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.21 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.1% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MVMFKKIKS FEVVFNDPEK VYGSGEKVAG RVIVEVCEVT RVKAVRILAC GVAKVLWMQG SQQCKQTSEY LRYEDTLLLE DQPTGENEMV IMRPGNKYEY KFGFELPQGP LGTSFKGKYG CVDYWVKAFL DRPSQPTQET KKNFEVVDLV DVNTPDLMAP VSAKKEKKVS CMFIPDGRVS VSARIDRKGF CEGDEISIHA DFENTCSRIV VPKAAIVARH TYLANGQTKV LTQKLSSVRG NHIISGTCAS WRGKSLRVQK IRPSILGCNI LRVEYSLLIY VSVPGSKKVI LDLPLVIGSR SGLSSRTSSM ASRTSSEMSW VDLNIPDTPE APPCYMDVIP EDHRLESPTT PLLDDMDGSQ DSPIFMYAPE FKFMPPPTYT EVDPCILNNN VQ (1-391 aa encoded by BC093702)

Target Information

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Verapamil Ameliorates Hepatic Metaflammation by Inhibiting Thioredoxin-Interacting Protein/NLRP3 Pathways.

Frontiers in endocrinology

Zhou F,Zhang Y,Chen J,Hu Y,Xu Y

Wed Nov 20 00:00:00 EST 2019

Triptolide impairs thioredoxin system by suppressing Notch1-mediated PTEN/Akt/Txnip signaling in hepatocytes.

Toxicology letters

Shen F,Xiong Z,Kong J,Wang L,Cheng Y,Jin J,Huang Z

Tue Jan 01 00:00:00 EST 2019

Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

He W,Ye S,Zeng C,Xue S,Hu X,Zhang X,Gao S,Xiong Y,He X,Vivalda S,Li L,Wang Y,Ye Q

Tue Jun 05 00:00:00 EDT 2018

Hypothermic oxygenated perfusion (HOPE) attenuates ischemia/reperfusion injury in the liver through inhibition of the TXNIP/NLRP3 inflammasome pathway in a rat model of donation after cardiac death.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

He W,Ye S,Zeng C,Xue S,Hu X,Zhang X,Gao S,Xiong Y,He X,Vivalda S,Li L,Wang Y,Ye Q

Tue Jun 05 00:00:00 EDT 2018

Effects of Hypobaric Hypoxia on Rat Retina and Protective Response of Resveratrol to the Stress.

International journal of medical sciences

Xin X,Dang H,Zhao X,Wang H

Mon May 21 00:00:00 EDT 2018

Nrf2 inhibits NLRP3 inflammasome activation through regulating Trx1/TXNIP complex in cerebral ischemia reperfusion injury.

Behavioural brain research

Hou Y,Wang Y,He Q,Li L,Xie H,Zhao Y,Zhao J

Mon Jan 15 00:00:00 EST 2018

Altered Expression of TXNIP in the peripheral leukocytes of patients with coronary atherosclerotic heart disease.

Medicine

Zhang Y,Huang J,Yang X,Sun X,Xu Q,Wang B,Zhong P,Wei Z

Fri Dec 01 00:00:00 EST 2017

Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas.

International journal of clinical oncology

Cai Z,Zhang C,Zou Y,Lu C,Hu H,Qian J,Jiang L,Hu G

Tue Aug 01 00:00:00 EDT 2017

Nuclear receptors regulate lipid metabolism and oxidative stress markers in chondrocytes.

Journal of molecular medicine (Berlin, Germany)

Ratneswaran A,Sun MM,Dupuis H,Sawyez C,Borradaile N,Beier F

Sat Apr 01 00:00:00 EDT 2017

Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways.

Biochimica et biophysica acta

He K,Hu Y,Ma H,Zou Z,Xiao Y,Yang Y,Feng M,Li X,Ye X

Thu Sep 01 00:00:00 EDT 2016

Hypolipidemic effects of Myrica rubra extracts and main compounds in C57BL/6j mice.

Food & function

He K,Li X,Xiao Y,Yong Y,Zhang Z,Li S,Zhou T,Yang D,Gao P,Xin X

Wed Aug 10 00:00:00 EDT 2016

FBW7 (F-box and WD Repeat Domain-Containing 7) Negatively Regulates Glucose Metabolism by Targeting the c-Myc/TXNIP (Thioredoxin-Binding Protein) Axis in Pancreatic Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Ji S,Qin Y,Liang C,Huang R,Shi S,Liu J,Jin K,Liang D,Xu W,Zhang B,Liu L,Liu C,Xu J,Ni Q,Chiao PJ,Li M,Yu X

Mon Aug 01 00:00:00 EDT 2016

New insights into salvianolic acid A action: Regulation of the TXNIP/NLRP3 and TXNIP/ChREBP pathways ameliorates HFD-induced NAFLD in rats.

Scientific reports

Ding C,Zhao Y,Shi X,Zhang N,Zu G,Li Z,Zhou J,Gao D,Lv L,Tian X,Yao J

Mon Jun 27 00:00:00 EDT 2016

ChREBP promotes the differentiation of leukemia-initiating cells to inhibit leukemogenesis through the TXNIP/RUNX1 pathways.

Oncotarget

Zeng H,Gu H,Chen C,Li M,Xia F,Xie L,Liu X,Zhang F,Tong X,Wang J,Yu Z,Zheng J

Tue Jun 21 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: hyperlipidemia 1; thioredoxin binding protein 2; thioredoxin binding protein-2; Thioredoxin-binding protein 2; Thioredoxin-interacting protein; upregulated by 1,25-dihydroxyvitamin D-3; Vitamin D3 up-regulated protein 1

Gene Aliases: 1200008J08Rik; AA682105; ARRDC6; EST01027; HHCPA78; Hyplip1; Tbp-2; THIF; TXNIP; VDUP1

UniProt ID: (Human) Q9H3M7, (Mouse) Q8BG60

Entrez Gene ID: (Human) 10628, (Mouse) 56338

Function(s)