Thioredoxins are a group of small redox active proteins possessing a conserved active site sequence. TrxL (Thioredoxin like protein 1) has 2 distinct domains: an N terminal domain, which is 43% identical to human TXN, and a C terminal domain, which shows no homology to other proteins in the sequence databases. The active site sequence, located within the N terminal domain, is that of a thioredoxin like protein; compared to the active site sequence of TXN, it has a single amino acid substitution. Unlike other thioredoxin like proteins, TrxL does not serve as a substrate for thioredoxin reductase in an insulin assay.
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Protein Aliases: 32 kDa thioredoxin-related protein; epididymis secretory protein Li 114; thioredoxin-like (32kD); thioredoxin-like 1; Thioredoxin-like protein 1; thioredoxin-related 32 kDa protein; Thioredoxin-related protein; thioredoxin-related protein 1
Gene Aliases: 32kDa; HEL-S-114; Trp; TRP32; TXL; TXL-1; TXNL; TXNL1
Molecular Function: oxidoreductase