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Product Details
16360-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TXNRD2 Fusion Protein Ag8367 (137-485 aa encoded by BC007489)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: EILLSADHI IIATGGRPRY PTHIEGALEY GITSDDIFWL KESPGKTLVV GASYVALECA GFLTGIGLDT TIMMRSIPLR GFDQQMSSMV IEHMASHGTR FLRGCAPSRV RRLPDGQLQV TWEDSTTGKE DTGTFDTVLW AIGRVPDTRS LNLEKAGVDT SPDTQKILVD SREATSVPHI YAIGDVVEGR PELTPIAIMA GRLLVQRLFG GSSDLMDYDN VPTTVFTPLE YGCVGLSEEE AVARHGQEHV EVYHAHYKPL EFTVAGRDAS QCYVKMVCLR EPPQLVLGLH FLGPNAGEVT QGFALGIKCG ASYAQVMRTV GIHPTCSEEV VKLRISKRSG LDPTVTGCUG (137-485 aa encoded by BC007489)
Target Information
The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxidoreductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence (-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55-58 kilodalton in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR plays a key role in protection of cells against oxidative stress and redox-regulatory mechanism of transcription factors and various biological phenomena.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Selenoprotein Z; SelZ; Thioredoxin reductase 2, mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR beta; TR-beta
Gene Aliases: AA118373; ESTM573010; KIAA1652; SELZ; TGR; TR; TR-BETA; TR3; TRXR2; Trxrd2; TXNRD2
UniProt ID: (Human) Q9NNW7, (Mouse) Q9JLT4, (Rat) Q9Z0J5
Entrez Gene ID: (Human) 10587, (Mouse) 26462, (Rat) 50551
thioredoxin-disulfide reductase activity
protein binding
flavin adenine dinucleotide binding
oxidoreductase activity
oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
protein homodimerization activity
mercury (II) reductase activity
mercury ion binding
protein dimerization activity
NADP binding
reductase
Performance Guarantee
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