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Invitrogen
TYK2 Polyclonal Antibody
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Product Details
PA5-34497
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide near the amino terminus of human TYK2
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is human small intestine tissue lysate.
PA5-34497 can be used with blocking peptide PEP-1539.
Antibodies should not be exposed to prolonged high temperatures.
Target Information
Tyrosine Kinase 2 (TYK2) a member of the JAK kinase family, plays both structural and catalytic roles in type I interferon (IFN) signaling. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; Non-receptor tyrosine-protein kinase TYK2; tyrosine kinase TYK2; unnamed protein product
Gene Aliases: IMD35; JTK1; TYK2
UniProt ID: (Human) P29597, (Mouse) Q9R117
Entrez Gene ID: (Human) 7297, (Rat) 100361294, (Mouse) 54721
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
growth hormone receptor binding
protein binding
ATP binding
kinase activity
transferase activity
type 1 angiotensin receptor binding
hormone receptor binding
transferase activity, transferring phosphorus-containing groups
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
immune response
JAK-STAT cascade
cell proliferation
cytokine-mediated signaling pathway
regulation of cell-cell adhesion
cell differentiation
positive regulation of interferon-gamma production
positive regulation of interleukin-17 production
positive regulation of natural killer cell proliferation
intracellular signal transduction
interleukin-12-mediated signaling pathway
interleukin-23-mediated signaling pathway
type III interferon-mediated signaling pathway
positive regulation of T cell proliferation
regulation of JAK-STAT cascade
positive regulation of JAK-STAT cascade
regulation of alpha-beta T cell activation
positive regulation of NK T cell proliferation
interferon-gamma-mediated signaling pathway
type I interferon signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
cellular response to virus
interleukin-10-mediated signaling pathway
positive regulation of protein localization to nucleus
positive regulation of T-helper 17 type immune response
transmembrane receptor protein tyrosine kinase signaling pathway
cell migration
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
phosphorylation
peptidyl-tyrosine phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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