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Invitrogen
TYMP Polyclonal Antibody
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Product Details
PA5-102352
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TYMP(Accession P19971), corresponding to amino acid residues M1-G46.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TYMP.
Target Information
A platelet-derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: endothelial cell growth factor 1 (platelet-derived); Gliostatin; OTTHUMP00000196767; OTTHUMP00000196770; PD TP; PD-ECGF; platelet derived growth factor, endothelial cell; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine phosphorylase; TP
Gene Aliases: 2900072D10Rik; ECGF; ECGF1; hPD-ECGF; MEDPS1; MNGIE; MTDPS1; PD-ECGF; PDECGF; Pdgfec; TP; TYMP
UniProt ID: (Human) P19971, (Rat) Q5FVR2, (Mouse) Q99N42
Entrez Gene ID: (Human) 1890, (Rat) 315219, (Mouse) 72962
phosphorylase activity
platelet-derived growth factor receptor binding
growth factor activity
thymidine phosphorylase activity
pyrimidine-nucleoside phosphorylase activity
transferase activity, transferring pentosyl groups
molecular_function
transferase activity
transferase activity, transferring glycosyl groups
glycosyltransferase
oxidase
mitochondrial genome maintenance
angiogenesis
pyrimidine nucleobase metabolic process
pyrimidine nucleotide metabolic process
DNA replication
chemotaxis
cell differentiation
pyrimidine nucleoside salvage
pyrimidine nucleoside catabolic process
pyrimidine nucleoside metabolic process
biological_process
metabolic process
organ morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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