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Proteintech
TYRO3 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
28513-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TYRO3 Fusion Protein Ag29540
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
800 µg/mL
Amount
120 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bruton agammaglobulinemia tyrosine kinase; FLJ16467; putative growth factor receptor kinase isoform B; putative growth factor receptor tyrosine kinase isoform A precursor; receptor tyrosine kinase; soluble tyro 3; soluble tyro3; styro 3; styro3; tyro 3; TYRO3; TYRO3 protein tyrosine kinase 3; tyrosine-protein kinase byk; tyrosine-protein kinase DTK; tyrosine-protein kinase RSE; tyrosine-protein kinase SKY; tyrosine-protein kinase TIF; unnamed protein product
Gene Aliases: Brt; BYK; Dtk; Etk-2; etk2/tyro3; Rek; RSE; Sky; Tif; tk19-1; TK19-2
UniProt ID: (Human) Q06418, (Mouse) P55144, (Rat) P55146
Entrez Gene ID: (Human) 7301, (Mouse) 22174, (Rat) 25232
phagocytosis
cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
spermatogenesis
nervous system development
cell migration
forebrain cell migration
platelet activation
secretion by cell
negative regulation of toll-like receptor signaling pathway
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
negative regulation of innate immune response
viral entry into host cell
negative regulation of inflammatory response
positive regulation of protein kinase B signaling
neuron cellular homeostasis
platelet aggregation
positive regulation of viral life cycle
natural killer cell differentiation
protein phosphorylation
neuropeptide signaling pathway
gamete generation
negative regulation of lymphocyte activation
vagina development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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