|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (494 TLDSLGISDELKEKLEDV 511) of TYRO3 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||0.25-1 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
TYRO3 is an 890 amino acid membrane protein belonging to the protein kinase superfamily, Tyr protein kinase family and AXL/UFO subfamily, with two fibronectin type-III domains, two Ig like C2 type domains and a protein kinase domain. The receptor TYRO3, along with other receptor tyrosine kinases like Axl and Mer, form the Axl/Tyro3 family and play essential roles in spermatogenesis, immunoregulation, and phagocytosis. The kinase activity of all these three receptors is activated by the product of growth arrest-specific gene, Gas6. In addition to signal transduction, they may participate in cell adhesion, particularly in the central nervous system and also as cell entry factor of filoviruses. TYRO3 and other receptor tyrosine kinases interact with RanBPM and are suspected to play some role in tumorigenesis, inflammation as well as other cell proliferative diseases. It is expressed abundantly in brain and with less abundance in other tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.