Search
Alomone Labs, LTD
TYRO3 (extracellular) Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 4
TYRO3 (extracellular) Antibody (ATR-031-200UL) in WB
Western blot analysis of human THP-1 monocytic leukemia cell line lysate (lanes 1 and 3) and human K562 chronic myelogenous leukemia cell line lysate (lanes 2 and 4). 1-2: Anti-TYRO3 (extracellular) Antibody (#ATR-031) (1:200). 3-4: Anti-TYRO3 (extracellular) Antibody, preincubated with TYRO3 (extracellular) Blocking Peptide (BLP-TR031).
Product Details
ATR-031-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide RLAYQGQDTPEVLMD, corresponding to amino acid residues 368-382 of human AXL. Extracellular, N-term.
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: RLAYQGQDTPEVLMD
Reconstitution: 50 uL double distilled water (DDW). The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Bruton agammaglobulinemia tyrosine kinase; Etk2/tyro3; FLJ16467; soluble tyro 3; soluble tyro3; styro 3; styro3; TK19-2; tyro 3; TYRO3; TYRO3 protein tyrosine kinase 3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF; unnamed protein product
Gene Aliases: AI323366; Brt; BYK; DTK; Etk-2; etk2/tyro3; Rek; RSE; SKY; TIF; TK19-2; TYRO3
UniProt ID: (Human) Q06418, (Mouse) P55144, (Rat) P55146
Entrez Gene ID: (Human) 7301, (Mouse) 22174, (Rat) 25232
nucleotide binding
virus receptor activity
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
phosphatidylinositol 3-kinase binding
transferase activity, transferring phosphorus-containing groups
protein heterodimerization activity
transmembrane signal receptor
neuron migration
natural killer cell differentiation
phagocytosis
cell adhesion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
neuropeptide signaling pathway
spermatogenesis
nervous system development
cell migration
forebrain cell migration
platelet activation
secretion by cell
negative regulation of toll-like receptor signaling pathway
substrate adhesion-dependent cell spreading
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
negative regulation of innate immune response
lymphocyte activation
viral entry into host cell
negative regulation of inflammatory response
negative regulation of lymphocyte activation
neuron apoptotic process
establishment of localization in cell
positive regulation of protein kinase B signaling
vagina development
neuron cellular homeostasis
platelet aggregation
positive regulation of viral life cycle
protein phosphorylation
phosphorylation
peptidyl-tyrosine phosphorylation
protein autophosphorylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support