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Immunogen sequence: RRAMITPALR EALTKQGYQL IGSHSGVKLC RWTKSMLRGR GGCYKHTFYG IESHRCMETT PSLACANKCV FCWRHHTNPV GTEWRWKMDQ PEMILKEAIE NHQNMIKQFK GVPGVKA
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 96%.
TYW1, also known as TYW1A, RSAFD1 or YPL207W, is a 732 amino acid protein containing one flavodoxin-like domain that participates in the wybutosine-tRNA (Phe) biosynthesis pathway. Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TYW1 is involved in a multistep enzymatic reaction that stabilizes codon-anticodon base-pairing during the ribosomal decoding process, thereby ensuring correct translation. TYW1 binds to one 4Fe-4S cluster and is located on human chromosome 7. Defects in some of the genes on chromosome 7 have been linked to Osteogenesis imperfecta, Williams-Beuren syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome, suggesting that TYW1 may play a role in these conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; radical S-adenosyl methionine and flavodoxin domains 1; S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW synthesizing protein 1 homolog A; tRNA-yW-synthesizing protein
Gene Aliases: RSAFD1; TYW1; TYW1A; YPL207W
UniProt ID: (Human) Q9NV66
Entrez Gene ID: (Human) 55253
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