Recommended positive controls: 293T, A431, HeLa, HepG2, Rat2.
Predicted reactivity: Rat (80%), Bovine (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD).
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Protein Aliases: Protein Tara; tara-like protein; TRIO and F-actin-binding protein; Trio-associated repeat on actin
Gene Aliases: DFNB28; dJ37E16.4; HRIHFB2122; KIAA1662; TAP68; TARA; TRIOBP
UniProt ID: (Human) Q9H2D6