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Themis is a cytoplasmic protein that is essential for positive selection and the development of single-positive thymocytes. Highest levels of expression are found in CD4+CD8+ double-positive thymocytes, with lower expression found in mature T cells. In addition to Grb1, Themis has been found to associate with PLC gamma 1 and LAT and is quickly phosphorylated by SLP-76 following TCR signaling. There are 5 isoforms of mouse Themis that are produced as a result of alternative splicing.
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Protein Aliases: bA325O24.3; bA325O24.4; FLJ40584; GRB2-associated protein; MGC163388; Protein THEMIS; signaling phosphoprotein specific for T cells; thymocyte expressed molecule involved in selection; thymocyte selection pathway associated; Thymocyte-expressed molecule involved in selection
Gene Aliases: C6orf190; C6orf207; GASP; SPOT; THEMIS; TSEPA
UniProt ID: (Human) Q8N1K5
Entrez Gene ID: (Human) 387357
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