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Invitrogen
Thrombin Polyclonal Antibody
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Product Details
PA1-43040
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Rodent
Host/Isotype
Sheep
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Purified Human Thrombin.
Conjugate
Form
Liquid
Concentration
12.5 mg/mL
Purification
SDS-PAGE
Storage buffer
50% water with 50% glycerol
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-43040 detects Thrombin in human and mouse samples.
PA1-43040 has successfully been used in Western blot and ELISA applications.
PA1-43040 was derived from purified human thrombin.
Target Information
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Coagulation factor II; coagulation factor II (thrombin); prepro-coagulation factor II; Prothombin; Prothrombin; prothrombin B-chain; serine protease
Gene Aliases: Cf-2; Cf2; F2; FII; PT; RPRGL2; THPH1
UniProt ID: (Mouse) P19221, (Human) P00734
Entrez Gene ID: (Mouse) 14061, (Human) 2147
positive regulation of protein phosphorylation
signal peptide processing
proteolysis
ER to Golgi vesicle-mediated transport
acute-phase response
cell surface receptor signaling pathway
multicellular organism development
blood coagulation
blood coagulation, intrinsic pathway
positive regulation of cell proliferation
regulation of cell shape
response to wounding
regulation of gene expression
negative regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase signaling
response to inactivity
peptidyl-glutamic acid carboxylation
platelet activation
regulation of blood coagulation
positive regulation of blood coagulation
positive regulation of cell growth
positive regulation of collagen biosynthetic process
fibrinolysis
cellular protein metabolic process
negative regulation of proteolysis
negative regulation of astrocyte differentiation
leukocyte migration
positive regulation of release of sequestered calcium ion into cytosol
regulation of cytosolic calcium ion concentration
negative regulation of fibrinolysis
cellular response to mechanical stimulus
positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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