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|Tested species reactivity||Human|
|Host / Isotype||Sheep / IgG|
|Immunogen||Thrombin (active site blocked) from bovine prothrombin.|
|Storage buffer||0.01M HEPES, pH 7.4, with 0.15M NaCl, 50% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Immunoelectrophoresis (IE)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-74124 detects Thrombin from human samples. Reacts weakly with mouse, pig, and rat.
PA1-74124 has been successfully used in ELISA and immunoelectrophoresis applications.
The PA1-74124 immunogen is Thrombin (active site blocked) from bovine prothrombin.
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
prepro-coagulation factor II; prothrombin; prothrombin B-chain; serine protease
PT; RPRGL2; THPH1