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Bioss
Thromboxane synthase Polyclonal Antibody
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Product Details
BS-4019R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Thromboxane synthase, amino acids 451-533.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Thromboxane synthase encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytochrome P450 5A1; cytochrome P450, family 5, subfamily A, polypeptide 1; FLJ52771; Hydroperoxy icosatetraenoate dehydratase; platelet, cytochrome P450, subfamily V; ThromboxA ane synthase 1; thromboxane A synthase 1 (platelet); Thromboxane-A synthase; TS; TXA synthase; TXS
Gene Aliases: BDPLT14; CYP5; CYP5A1; GHOSAL; TBXAS1; THAS; TS; TXAS; TXS
UniProt ID: (Human) E7EMU9, (Mouse) P36423, (Rat) P49430
Entrez Gene ID: (Human) 6916, (Mouse) 21391, (Rat) 24886
monooxygenase activity
thromboxane-A synthase activity
iron ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
heme binding
12-hydroxyheptadecatrienoic acid synthase activity
oxidoreductase activity
isomerase activity
metal ion binding
molecular_function
isomerase
metabolite interconversion enzyme
icosanoid metabolic process
cyclooxygenase pathway
oxidation-reduction process
prostaglandin biosynthetic process
lipid metabolic process
fatty acid metabolic process
fatty acid biosynthetic process
prostaglandin metabolic process
cellular chloride ion homeostasis
positive regulation of vasoconstriction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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