Tom22 has a negatively charged N-terminal region exposed to the cytosol, a putative transmembrane region, and a C-terminal intermembrane space region with little negative charge. The following functions can be assigned to the three domains of Tom22: the cytosolic N-terminal domain plays a dual role, specifically important for presequence binding; the intermembrane space domain provides a trans binding site for presequences, and the single membrane anchor of Tom22 is crucial for the integrity of the GIP (general import gene) complex. The TOM complex of mammalian mitochondria resembles the fungal Tom complex, but is distinct from the plant TOM system. Thus, while unique components of the mammalian mitochondrial import system have been identified (e. g. TOM34 and metaxin), Tom22, and Tom37 have not been identified in plant mitochondria.
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Protein Aliases: 1C9-2; hTom22; Mitochondrial import receptor subunit TOM22 homolog; mitochondrial import receptor Tom22; rTOM22; Translocase of outer membrane 22 kDa subunit homolog; translocase of outer mitochondrial membrane 22 homolog
Gene Aliases: 1C9-2; 2310047D01; MST065; MSTP065; rTOM22; TOM22; TOMM22
Molecular Function: primary active transporter