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Invitrogen
Torc1 Polyclonal Antibody
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FIGURE: 1 / 4
Torc1 Antibody (PA5-17365) in ICC/IF
Immunofluorescence analysis of Torc1 was performed using 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Torc1 Rabbit Polyclonal Antibody (Product # PA5-17365) at 1:200 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product... View More
Product Details
PA5-17365
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues surrounding Gly296 of human TORC1 (CRTC1) protein
Conjugate
Form
Liquid
Concentration
70.5 µg/mL
Amount
7.05 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with TORC2 and TORC3 proteins.
Target Information
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CREB-regulated transcription coactivator 1; crtc1; FLJ14027; Mastermind-like protein 2; MECT 1; mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; Mucoepidermoid carcinoma translocated protein 1 homolog; TORC-1; transcriptional co-activator; transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1; unnamed protein product
Gene Aliases: AI413414; CRTC1; KIAA0616; Mam-2; MAML2; MECT1; mKIAA0616; R74955; TORC-1; TORC1; WAMTP1
UniProt ID: (Human) Q6UUV9, (Mouse) Q68ED7
Entrez Gene ID: (Human) 23373, (Mouse) 382056
memory
positive regulation of CREB transcription factor activity
entrainment of circadian clock by photoperiod
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
protein homotetramerization
cellular response to cAMP
energy homeostasis
negative regulation of membrane hyperpolarization
transcription, DNA-templated
regulation of transcription, DNA-templated
membrane hyperpolarization
positive regulation of dendrite development
positive regulation of long-term synaptic potentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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