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Invitrogen
Torc1 Monoclonal Antibody (2D4)
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Product Details
MA5-24872
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Mouse
/ IgM
Class
Monoclonal
Type
Antibody
Clone
2D4
Immunogen
Recombinant full length Human TORC1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CREB-regulated transcription coactivator 1; crtc1; FLJ14027; Mastermind-like protein 2; MECT 1; mucoepidermoid carcinoma translocated 1; Mucoepidermoid carcinoma translocated protein 1; Mucoepidermoid carcinoma translocated protein 1 homolog; TORC-1; transcriptional co-activator; transducer of CREB protein 1; transducer of regulated cAMP response element-binding protein (CREB) 1; Transducer of regulated cAMP response element-binding protein 1; unnamed protein product
Gene Aliases: AI413414; CRTC1; KIAA0616; Mam-2; MAML2; MECT1; mKIAA0616; R74955; TORC-1; TORC1; WAMTP1
UniProt ID: (Human) Q6UUV9, (Rat) Q157S1, (Mouse) Q68ED7
Entrez Gene ID: (Human) 23373, (Rat) 684527, (Mouse) 382056
memory
positive regulation of CREB transcription factor activity
entrainment of circadian clock by photoperiod
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
protein homotetramerization
cellular response to cAMP
energy homeostasis
negative regulation of membrane hyperpolarization
transcription, DNA-templated
membrane hyperpolarization
positive regulation of dendrite development
positive regulation of long-term synaptic potentiation
regulation of transcription, DNA-templated
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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