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Invitrogen

Transferrin Receptor Polyclonal Antibody

View all (139) Transferrin Receptor (CD71) antibodies

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Transferrin Receptor Polyclonal Antibody

Product Details

PA5-116065

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TFRC(Accession P02786), corresponding to amino acid residues M1-N50.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900699

Product Specific Information

Antibody detects endogenous levels of total Transferrin Receptor.

Target Information

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD antigen CD71; CD71; mammary tumor virus receptor 1; p90; T9; TR; transferrin receptor; Transferrin receptor 1; Transferrin receptor protein 1; unnamed protein product

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Gene Aliases: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; IMD46; Mtvr-1; Mtvr1; p90; T9; TFR; TFR1; TFRC; TR; TRFR

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UniProt ID: (Human) Q1HE24, (Mouse) Q62351

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Entrez Gene ID: (Human) 7037, (Mouse) 22042

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Function(s)
virus receptor activity RNA binding double-stranded RNA binding transferrin receptor activity protein binding protein kinase binding Hsp70 protein binding identical protein binding protein homodimerization activity macromolecular complex binding chaperone binding glycoprotein binding iron ion transmembrane transporter activity transferrin transmembrane transporter activity poly(A) RNA binding metalloprotease
Process(es)
regulation of cell growth response to hypoxia iron ion transport cellular iron ion homeostasis endocytosis receptor-mediated endocytosis acute-phase response signal transduction cell surface receptor signaling pathway response to nutrient response to iron ion response to manganese ion positive regulation of gene expression negative regulation of mitochondrial fusion osteoclast differentiation positive regulation of B cell proliferation positive regulation of protein complex assembly receptor internalization response to retinoic acid transferrin transport intracellular signal transduction positive regulation of T cell proliferation regulation of cell proliferation negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of isotype switching response to copper ion viral entry into host cell multicellular organismal iron ion homeostasis cellular response to xenobiotic stimulus regulation of postsynaptic membrane neurotransmitter receptor levels transport across blood-brain barrier positive regulation of protein localization to nucleus cellular response to leukemia inhibitory factor iron ion transmembrane transport cellular response to drug positive regulation of bone resorption protein transmembrane transport iron ion import
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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