PA5-27739 targets CD71 in IHC (P) and WB applications and shows reactivity with Human and mouse samples.
The PA5-27739 immunogen is recombinant fragment corresponding to a region within amino acids 169 and 407 of Human CD71.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
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Protein Aliases: CD71; mammary tumor virus receptor 1; p90; sTfR; T9; TFR; TFR1; TR; Transferrin receptor protein 1; Transferrin receptor protein 1, serum form; TRFR
Gene Aliases: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; IMD46; Mtvr-1; Mtvr1; p90; T9; TFR; TFR1; TFRC; TR; TRFR
Molecular Function: receptor