This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
H68.4 is specific to residues 3-28 of the human transferrin receptor (TfR) tail.
CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. Upon binding of holotransferrin (complex of transferrin and iron ions), CD71 is internalized by clathrin-mediated endocytosis. Acidification of endosomes by vesicular membrane proton pumps leads to dissociation of iron ions, whereas transferrin (apotransferrin) remains associated with CD71 and recycles to the cell surface, where it is released upon exposure to normal pH. CD71 is also involved in uptake of non-transferrin bound iron.
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Protein Aliases: CD71; mammary tumor virus receptor 1; p90; sTfR; T9; TFR; TFR1; TR; Transferrin receptor protein 1; Transferrin receptor protein 1, serum form; TRFR
Gene Aliases: 2610028K12Rik; AI195355; AI426448; AU015758; CD71; E430033M20Rik; I79_000642; IMD46; Mtvr-1; Mtvr1; p90; T9; TFR; TFR1; TFRC; TR; TRFR
Molecular Function: receptor