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TrkA Polyclonal Antibody
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Product Details
OST00115W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Sheep
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the extracellular domain of rat TrkA conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TrkA.
Target Information
NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp781I14186; EC 2.7.10.1; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; TrkA neurotrophin receptor; trkA proto-oncogene receptor; tropomyosin-related kinase A
Gene Aliases: Ntrk1; Trk; Trka
UniProt ID: (Rat) P35739
Entrez Gene ID: (Rat) 59109
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
neurotrophin p75 receptor binding
protein binding
ATP binding
nerve growth factor receptor activity
kinase binding
protein homodimerization activity
ephrin receptor binding
nerve growth factor binding
transmembrane signal receptor
protein phosphorylation
nervous system development
axon guidance
aging
learning or memory
circadian rhythm
negative regulation of cell proliferation
response to radiation
programmed cell death involved in cell development
positive regulation of neuron projection development
response to activity
peptidyl-tyrosine phosphorylation
sensory perception of pain
olfactory nerve development
B cell differentiation
response to nutrient levels
response to nicotine
nerve growth factor signaling pathway
mechanoreceptor differentiation
response to drug
positive regulation of programmed cell death
negative regulation of neuron apoptotic process
response to ethanol
positive regulation of angiogenesis
positive regulation of Ras protein signal transduction
protein autophosphorylation
neurotrophin TRK receptor signaling pathway
sympathetic nervous system development
response to axon injury
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of NF-kappaB transcription factor activity
response to hydrostatic pressure
response to electrical stimulus
positive regulation of synaptic transmission, glutamatergic
Sertoli cell development
axonogenesis involved in innervation
positive regulation of ERK1 and ERK2 cascade
cellular response to nicotine
cellular response to growth factor stimulus
negative regulation of neuron death
cellular response to nerve growth factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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