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          • Primary Antibodies ›
          • TrkA/TrkB Antibodies

          Invitrogen

          TrkA/TrkB Polyclonal Antibody

          View all (7) TrkA/TrkB antibodies

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          Cite TrkA/TrkB Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          TrkA/TrkB Antibody in Western Blot (WB)
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          TrkA/TrkB Antibody in Western Blot (WB)
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          TrkA/TrkB Antibody (PA5-105255) in WB

          Western blot analysis of TrkA/TrkB in Jurkat cell lysate (left lane: treated with blocking peptide). Samples were incubated with TrkA/TrkB polyclonal antibody (Product # PA5-105255). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          TrkA/TrkB Antibody in Western Blot (WB)
          TrkA/TrkB Polyclonal Antibody

          Product Details

          PA5-105255

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:500-1:2,000
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human NTRK1(Accession P04629), corresponding to amino acid residues R771-G796.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2816720

          Product Specific Information

          Antibody detects endogenous levels of total TrkA /TrkB.

          Target Information

          This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; gp140trk; GP145-TrkB; GP145-TrkB/GP95-TrkB; High affinity nerve growth factor receptor; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine receptor kinase type 2; NTRK2; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; trk; trk tyrosine-specific protein kinase; Trk-A; Trk-B; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; TrkB; TrkB tyrosine kinase; TrkB-T-Shc; tropomyosin receptor kinase A; Tropomyosin-related kinase A; Tropomyosin-related kinase B; truncated trkB; Tyrosine kinase receptor; Tyrosine kinase receptor A; tyrosine kinase receptor B; unnamed protein product

          View more View less

          Gene Aliases: C80751; DEE58; EIEE58; GP145-TrkB; GP145-TrkB/GP95-TrkB; MTC; NTRK1; NTRK2; OBHD; p140-TrkA; RATTRKB1; Tkr; Tkrb; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB; TRKB1

          View more View less

          UniProt ID: (Human) P04629, (Human) Q16620, (Mouse) Q3UFB7, (Rat) P35739, (Mouse) P15209, (Rat) Q63604

          View more View less

          Entrez Gene ID: (Human) 4914, (Human) 4915, (Mouse) 18211, (Rat) 59109, (Mouse) 18212, (Rat) 25054

          View more View less

          Function(s)
          nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase activity transferase activity kinase binding identical protein binding protein homodimerization activity neurotrophin binding nerve growth factor binding protease binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity transferase activity, transferring phosphorus-containing groups ephrin receptor binding transmembrane signal receptor
          Process(es)
          protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway spermatogenesis nervous system development axon guidance learning or memory circadian rhythm negative regulation of cell proliferation response to xenobiotic stimulus programmed cell death involved in cell development positive regulation of neuron projection development peptidyl-tyrosine phosphorylation olfactory nerve development cell differentiation B cell differentiation neuron projection development response to nutrient levels response to nicotine peptidyl-tyrosine autophosphorylation nerve growth factor signaling pathway mechanoreceptor differentiation negative regulation of apoptotic process positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of GTPase activity positive regulation of angiogenesis positive regulation of Ras protein signal transduction protein autophosphorylation neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway sympathetic nervous system development neuron development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity neuron apoptotic process response to hydrostatic pressure response to electrical stimulus positive regulation of protein kinase B signaling positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to growth factor stimulus cellular response to beta-amyloid cellular response to nerve growth factor stimulus vasculogenesis neuron migration learning feeding behavior positive regulation of cell proliferation positive regulation of gene expression glutamate secretion regulation of metabolic process neuronal action potential propagation central nervous system neuron development cerebral cortex development myelination in peripheral nervous system neuron differentiation brain-derived neurotrophic factor receptor signaling pathway neurotrophin signaling pathway regulation of GTPase activity positive regulation of MAPK cascade retinal rod cell development oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of protein kinase B signaling retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus trans-synaptic signaling by BDNF, modulating synaptic transmission negative regulation of beta-amyloid formation cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis multicellular organism development response to activity phosphorylation sensory perception of pain response to drug negative regulation of neuron death aging response to radiation response to ethanol neuromuscular junction development long-term memory positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source regulation of MAPK cascade regulation of neurotransmitter secretion regulation of dendrite development positive regulation of glucocorticoid receptor signaling pathway inflammatory response response to light stimulus response to auditory stimulus cellular response to tumor necrosis factor
          It has to be done as per old AB suggested Products section.

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