Invitrogen

TrkA/TrkB/TrkC Recombinant Rabbit Monoclonal Antibody (RM423)

View all (12) TrkA/TrkB/TrkC antibodies

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TrkA/TrkB/TrkC Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical staining of formalin fixed and paraffin embedded human brain tissue section using TrkA/TrkB/TrkC rabbit monoclonal antibody (Product # MA5-36218) at a 1:100 dilution.

TrkA/TrkB/TrkC Antibody in Western Blot (WB) — Western Blot of mouse brain tissue lysate using TrkA/TrkB/TrkC rabbit monoclonal antibody (Product # MA5-36218) at a 1:2,000 dilution.

Product Details

MA5-36218

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

RM423

Immunogen

A peptide corresponding to the C-terminus of human TRK

Conjugate

Unconjugated

Form

Liquid

Concentration

0.08 mg/mL

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 1% BSA

Contains

0.09% sodium azide

Storage conditions

-20°C

RRID

AB_2884052

Product Specific Information

MA5-36218 reacts to human TRK. This antibody may also react to mouse or rat TRK, as predicted by immunogen homology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; gp140trk; GP145-TrkB; GP145-TrkC; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; Oncogene TRK; p140-TrkA; Trk-A; Trk-B; Trk-C; TRK1-transforming tyrosine kinase protein; TrkB tyrosine kinase; TrkC tyrosine kinase; Tropomyosin-related kinase A; Tropomyosin-related kinase B; Tyrosine kinase receptor; Tyrosine kinase receptor A; tyrosine kinase receptor B; tyrosine kinase receptor C

Gene Aliases: gp145(trkC); GP145-TrkB; GP145-TrkC; MTC; NTRK1; NTRK2; NTRK3; p140-TrkA; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB; TRKC

UniProt ID: (Human) Q9UIU7, (Human) Q16620, (Human) Q16288

Entrez Gene ID: (Human) 4914, (Human) 4915, (Human) 4916

Molecular Function: immunoglobulin superfamily cell adhesion molecule transmembrane signal receptor

activation of MAPKK activity positive regulation of protein phosphorylation protein phosphorylation microtubule-based movement axon guidance aging learning or memory circadian rhythm negative regulation of cell proliferation response to radiation programmed cell death involved in cell development positive regulation of neuron projection development response to activity peptidyl-tyrosine phosphorylation olfactory nerve development B cell differentiation response to nutrient levels nerve growth factor signaling pathway mechanoreceptor differentiation response to drug positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of GTPase activity response to ethanol positive regulation of Ras protein signal transduction protein autophosphorylation neurotrophin TRK receptor signaling pathway ephrin receptor signaling pathway phosphatidylinositol-mediated signaling sympathetic nervous system development response to axon injury detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity response to hydrostatic pressure response to electrical stimulus positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development axonogenesis involved in innervation behavioral response to formalin induced pain positive regulation of ERK1 and ERK2 cascade cellular response to nicotine cellular response to nerve growth factor stimulus vasculogenesis neuron migration inflammatory response neuromuscular junction development learning long-term memory feeding behavior positive regulation of cell proliferation response to light stimulus positive regulation of gene expression response to auditory stimulus glutamate secretion positive regulation of phosphatidylinositol 3-kinase signaling central nervous system neuron development cerebral cortex development neuron differentiation brain-derived neurotrophic factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source neurotrophin signaling pathway regulation of GTPase activity positive regulation of MAPK cascade retinal rod cell development regulation of neurotransmitter secretion oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development regulation of protein kinase B signaling retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus cellular response to tumor necrosis factor cellular response to brain-derived neurotrophic factor stimulus negative regulation of anoikis activation of MAPK activity negative regulation of protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway heart development modulation by virus of host transcription positive regulation of cell migration activation of protein kinase B activity positive regulation of apoptotic process neuron fate specification positive regulation of axon extension involved in regeneration negative regulation of astrocyte differentiation positive regulation of positive chemotaxis response to corticosterone negative regulation of cell death lens fiber cell differentiation cellular response to retinoic acid cochlea development activation of GTPase activity positive regulation of actin cytoskeleton reorganization

Process(es)

transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase binding protein homodimerization activity neurotrophin binding nerve growth factor binding receptor tyrosine kinase binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity p53 binding neurotrophin receptor activity