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Proteintech
TrkB Polyclonal Antibody
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Product Details
13129-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Published species
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TrkB Fusion Protein Ag3790 (41-433 aa encoded by BC031835)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SRIWCSDPS PGIVAFPRLE PNSVDPENIT EIFIANQKRL EIINEDDVEA YVGLRNLTIV DSGLKFVAHK AFLKNSNLQH INFTRNKLTS LSRKHFRHLD LSELILVGNP FTCSCDIMWI KTLQEAKSSP DTQDLYCLNE SSKNIPLANL QIPNCGLPSA NLAAPNLTVE EGKSITLSCS VAGDPVPNMY WDVGNLVSKH MNETSHTQGS LRITNISSDD SGKQISCVAE NLVGEDQDSV NLTVHFAPTI TFLESPTSDH HWCIPFTVKG NPKPALQWFY NGAILNESKY ICTKIHVTNH TEYHGCLQLD NPTHMNNGDY TLIAKNEYGK DEKQISAHFM GWPGIDDGAN PNYPDVIYED YGTAANDIGD TTNRSNEIPS TDVTDKTGRE HLSV (41-433 aa encoded by BC031835)
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AI848316; BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP145TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; NTRK2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; Trk B; Trk-B; TrkB; trkB protein; TrkB tyrosine kinase; TrkB-T-Shc; Tropomyosin-related kinase B; truncated trkB; tyrosine kinase receptor B; unnamed protein product
Gene Aliases: DEE58; EIEE58; GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2; OBHD; RATTRKB1; Tkrb; trk-B; TRKB; TRKB1
UniProt ID: (Human) Q16620, (Mouse) P15209, (Rat) Q63604
Entrez Gene ID: (Pig) 100519209, (Human) 4915, (Mouse) 18212, (Rat) 25054
nucleotide binding
protease binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
neurotrophin receptor activity
protein binding
ATP binding
kinase activity
transferase activity
protein homodimerization activity
neurotrophin binding
brain-derived neurotrophic factor binding
brain-derived neurotrophic factor-activated receptor activity
transferase activity, transferring phosphorus-containing groups
ephrin receptor binding
transmembrane signal receptor
vasculogenesis
neuron migration
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
learning
circadian rhythm
feeding behavior
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of neuron projection development
glutamate secretion
regulation of metabolic process
neuronal action potential propagation
central nervous system neuron development
cerebral cortex development
myelination in peripheral nervous system
cell differentiation
neuron differentiation
brain-derived neurotrophic factor receptor signaling pathway
neurotrophin signaling pathway
mechanoreceptor differentiation
regulation of GTPase activity
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
retinal rod cell development
protein autophosphorylation
oligodendrocyte differentiation
peripheral nervous system neuron development
positive regulation of axonogenesis
regulation of protein kinase B signaling
positive regulation of protein kinase B signaling
positive regulation of synapse assembly
retina development in camera-type eye
long-term synaptic potentiation
cellular response to amino acid stimulus
trans-synaptic signaling by BDNF, modulating synaptic transmission
negative regulation of beta-amyloid formation
cellular response to brain-derived neurotrophic factor stimulus
negative regulation of anoikis
protein phosphorylation
multicellular organism development
neuromuscular junction development
long-term memory
positive regulation of phosphatidylinositol 3-kinase signaling
phosphorylation
peptidyl-tyrosine phosphorylation
positive regulation of peptidyl-serine phosphorylation
calcium-mediated signaling using intracellular calcium source
regulation of MAPK cascade
regulation of neurotransmitter secretion
regulation of dendrite development
positive regulation of synaptic transmission, glutamatergic
positive regulation of glucocorticoid receptor signaling pathway
inflammatory response
aging
response to light stimulus
response to auditory stimulus
cellular response to tumor necrosis factor
cellular response to nerve growth factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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