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Product Details
PA5-120787
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 32-430 of human TrkB (NP_0010180741)
Conjugate
Form
Liquid
Concentration
1.00 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2914359
Product Specific Information
Positive test controls include: Mouse brain, Rat brain. The target is usually found in the following locations: Cell membrane, Endosome membrane, Single-pass type I membrane protein.
Immunogen sequence: CPTSCKCSAS RIWCSDPSPG IVAFPRLEPN SVDPENITEI FIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAHKAF LKNSNLQHIN FTRNKLTSLS RKHFRHLDLS ELILVGNPFT CSCDIMWIKT LQEAKSSPDT QDLYCLNESS KNIPLANLQI PNCGLPSANL AAPNLTVEEG KSITLSCSVA GDPVPNMYWD VGNLVSKHMN ETSHTQGSLR ITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVKGNP KPALQWFYNG AILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL IAKNEYGKDE KQISAHFMGW PGIDDGANPN YPDVIYEDYG TAANDIGDTT NRSNEIPSTD VTDKTGREH
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses. TrkB is involved in the development and maintenance of the nervous system. Moreover, Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI848316; BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; C030027L06Rik; EC 2.7.10.1; GP145 TrkB; GP145-TrkB; GP145-TrkB/GP95-TrkB; GP145TrkB; GP95 TrkB; GP95-TrkB; hyperphagia; kinase TrkB; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; NTRK 2; OTTHUMP00000021573; OTTHUMP00000021574; OTTHUMP00000021576; OTTHUMP00000021577; Trk B; Trk-B; TrkB tyrosine kinase; Tropomyosin-related kinase B; tyrosine kinase receptor B
Gene Aliases: GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2; RATTRKB1; Tkrb; trk-B; TRKB; TRKB1
UniProt ID: (Human) Q16620, (Mouse) Q3TUF9, (Rat) Q63604
Entrez Gene ID: (Human) 4915, (Mouse) 18212, (Rat) 25054
ATP binding
receptor tyrosine kinase binding
protein homodimerization activity
neurotrophin binding
brain-derived neurotrophic factor binding
brain-derived neurotrophic factor-activated receptor activity
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
neurotrophin receptor activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
ephrin receptor binding
transmembrane signal receptor
immunoglobulin superfamily cell adhesion molecule
vasculogenesis
neuron migration
positive regulation of protein phosphorylation
inflammatory response
neuromuscular junction development
aging
learning
long-term memory
circadian rhythm
feeding behavior
positive regulation of cell proliferation
response to light stimulus
positive regulation of gene expression
positive regulation of neuron projection development
response to auditory stimulus
glutamate secretion
positive regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
central nervous system neuron development
cerebral cortex development
neuron differentiation
brain-derived neurotrophic factor receptor signaling pathway
positive regulation of peptidyl-serine phosphorylation
calcium-mediated signaling using intracellular calcium source
neurotrophin signaling pathway
mechanoreceptor differentiation
regulation of GTPase activity
positive regulation of MAPK cascade
negative regulation of neuron apoptotic process
retinal rod cell development
protein autophosphorylation
regulation of neurotransmitter secretion
oligodendrocyte differentiation
peripheral nervous system neuron development
positive regulation of axonogenesis
regulation of dendrite development
regulation of protein kinase B signaling
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
retina development in camera-type eye
long-term synaptic potentiation
cellular response to amino acid stimulus
cellular response to tumor necrosis factor
cellular response to brain-derived neurotrophic factor stimulus
negative regulation of anoikis
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
nervous system development
phosphorylation
regulation of metabolic process
cell differentiation
regulation of MAPK cascade
positive regulation of glucocorticoid receptor signaling pathway
cellular response to nerve growth factor stimulus
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