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Proteintech
TrkC Polyclonal Antibody
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Product Details
11999-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TrkC Fusion Protein Ag2635 (36-350 aa encoded by BC013693)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: CVCSKTEIN CRRPDDGNLF PLLEGQDSGN SNGNASINIT DISRNITSIH IENWRSLHTL NAVDMELYTG LQKLTIKNSG LRSIQPRAFA KNPHLRYINL SSNRLTTLSW QLFQTLSLRE LQLEQNFFNC SCDIRWMQLW QEQGEAKLNS QNLYCINADG SQLPLFRMNI SQCDLPEISV SHVNLTVREG DNAVITCNGS GSPLPDVDWI VTGLQSINTH QTNLNWTNVH AINLTLVNVT SEDNGFTLTC IAENVVGMSN ASVALTVYYP PRVVSLEEPE LRLEHCIEFV VRGNPPPTLH WLHNGQPLRE SKIIHV (36-350 aa encoded by BC013693)
Target Information
NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin-3; NT-3 growth factor receptor; NTRK3; splice variant; TEL-TrkC fusion protein; Trk-C; trkC; TrkC tyrosine kinase; tyrosine kinase receptor C; unnamed protein product
Gene Aliases: AW125844; gp145(trkC); GP145-TrkC; NTRK3; Ntrk3_tv3; TRKC
UniProt ID: (Human) Q16288, (Mouse) Q6VNS1, (Rat) Q03351
Entrez Gene ID: (Human) 4916, (Mouse) 18213, (Rat) 29613
nucleotide binding
p53 binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
GPI-linked ephrin receptor activity
neurotrophin receptor activity
protein binding
ATP binding
kinase activity
transferase activity
neurotrophin binding
transferase activity, transferring phosphorus-containing groups
ephrin receptor binding
transmembrane signal receptor
neuron migration
cell communication
transmembrane receptor protein tyrosine kinase signaling pathway
nervous system development
heart development
circadian rhythm
positive regulation of cell proliferation
positive regulation of gene expression
positive regulation of neuron projection development
neuronal action potential propagation
myelination in peripheral nervous system
cell differentiation
positive regulation of cell migration
neurotrophin signaling pathway
mechanoreceptor differentiation
positive regulation of apoptotic process
positive regulation of MAPK cascade
response to ethanol
ephrin receptor signaling pathway
animal organ development
neuron fate specification
axon extension involved in regeneration
response to axon injury
positive regulation of axon extension involved in regeneration
negative regulation of astrocyte differentiation
system development
positive regulation of positive chemotaxis
response to corticosterone
positive regulation of protein kinase B signaling
positive regulation of synapse assembly
lens fiber cell differentiation
cellular response to retinoic acid
cochlea development
postsynaptic density assembly
regulation of presynapse assembly
cellular response to nerve growth factor stimulus
regulation of neural precursor cell proliferation
activation of MAPK activity
negative regulation of protein phosphorylation
protein phosphorylation
multicellular organism development
phosphorylation
activation of protein kinase B activity
positive regulation of peptidyl-serine phosphorylation
protein autophosphorylation
negative regulation of cell death
activation of GTPase activity
positive regulation of actin cytoskeleton reorganization
peptidyl-tyrosine phosphorylation
modulation by virus of host transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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