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TrkC Polyclonal Antibody
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Product Details
OST00334W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from the n-terminal region of mouse TrkC conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: TrkC.
Target Information
NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 3; neurotrophin-3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase
Gene Aliases: AW125844; Ntrk3; Ntrk3_tv3; TrkC
UniProt ID: (Mouse) Q6VNS1, (Rat) Q03351
Entrez Gene ID: (Mouse) 18213, (Rat) 29613
nucleotide binding
p53 binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
neurotrophin receptor activity
protein binding
ATP binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
ephrin receptor binding
transmembrane signal receptor
activation of MAPK activity
neuron migration
negative regulation of protein phosphorylation
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
nervous system development
positive regulation of cell proliferation
positive regulation of gene expression
phosphorylation
cell differentiation
positive regulation of cell migration
activation of protein kinase B activity
positive regulation of peptidyl-serine phosphorylation
neurotrophin signaling pathway
mechanoreceptor differentiation
positive regulation of apoptotic process
protein autophosphorylation
neuron fate specification
positive regulation of axon extension involved in regeneration
negative regulation of astrocyte differentiation
positive regulation of positive chemotaxis
positive regulation of synapse assembly
negative regulation of cell death
lens fiber cell differentiation
activation of GTPase activity
positive regulation of actin cytoskeleton reorganization
circadian rhythm
peptidyl-tyrosine phosphorylation
modulation by virus of host transcription
response to ethanol
response to axon injury
response to corticosterone
cellular response to retinoic acid
cochlea development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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