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Invitrogen

TrkC Polyclonal Antibody

View all (26) TrkC antibodies
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
433BB748-DC81-4FE4-83AD-384F97313745 Created with sketchtool. Create Citation
C488C313-B559-4BFD-B17D-A8B65492815A Created with sketchtool. Tech Support
635D49A6-4B57-425E-8DC4-6BA1AEB7B473 Created with sketchtool. Datasheet
433BB748-DC81-4FE4-83AD-384F97313745 Created with sketchtool. Create Citation
C488C313-B559-4BFD-B17D-A8B65492815A Created with sketchtool. Tech Support

Product Details

Tested Applications
Dilution
Immunohistochemistry (IHC)
1:50-1:200
Western Blot (WB)
1:500-1:2000
Product Specifications
Species Reactivity
Human, Mouse, Rat
Host / Isotype
Rabbit / IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human NTRK3
Conjugate
Unconjugated
Form
liquid
Concentration
1.91 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen sequence: KTEINCRRPD DGNLFPLLEG QDSGNSNGNA SINITDISRN ITSIHIENWR SLHTLNAVDM ELYTGLQKLT IKNSGLRSIQ PRAFAKNPHL RYINLSSNRL TTLSWQLFQT LSLRELQLEQ NFFNCSCDIR WMQLWQEQGE AKLNSQNLYC INADGSQLPL FRMNISQCDL PEISVSHVNL TVREGDNAVI TCNGSGSPLP DVDWIVTGLQ SINTHQTNLN WTNVHAINLT LVNVTSEDNG FTLTCIAENV VGMSNASVAL T; Positive Samples: A549, HepG2, Mouse liver; Cellular Location: Membrane, Single-pass type I membrane protein

Target Information

TRKC, a member of the insulin receptor subfamily of tyrosine protein kinases, is a receptor for neurotrophin-3 (NT-3). Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin-3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase; tyrosine kinase receptor C

Gene Aliases: AW125844; gp145(trkC); GP145-TrkC; NTRK3; Ntrk3_tv3; TRKC

UniProt ID: (Human) Q16288, (Mouse) Q6VNS1, (Rat) Q03351

Entrez Gene ID: (Human) 4916, (Mouse) 18213, (Rat) 29613

Function(s)
activation of MAPK activity neuron migration negative regulation of protein phosphorylation protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development positive regulation of cell proliferation positive regulation of gene expression phosphorylation cell differentiation positive regulation of cell migration activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation neurotrophin signaling pathway mechanoreceptor differentiation positive regulation of apoptotic process protein autophosphorylation neuron fate specification positive regulation of axon extension involved in regeneration negative regulation of astrocyte differentiation positive regulation of positive chemotaxis positive regulation of synapse assembly negative regulation of cell death lens fiber cell differentiation activation of GTPase activity positive regulation of actin cytoskeleton reorganization positive regulation of protein phosphorylation heart development circadian rhythm peptidyl-tyrosine phosphorylation modulation by virus of host transcription response to ethanol ephrin receptor signaling pathway response to axon injury response to corticosterone cellular response to retinoic acid cochlea development
Process(es)
p53 binding GPI-linked ephrin receptor activity neurotrophin receptor activity protein binding ATP binding neurotrophin binding nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ephrin receptor binding

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