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TrkCT1 Polyclonal Antibody

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TrkCT1 Polyclonal Antibody

Product Details

600-401-993

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

ELISA (ELISA)

1:5,000-1:20,000
-

Immunoprecipitation (IP)

1 µg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse TrkCT1 protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Directed against mouse TrkCT1 protein. A BLAST analysis was used to suggest cross-reactivity with TrkCT1 protein from human, mouse and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.

Target Information

NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin-3; NT-3 growth factor receptor; NTRK3; splice variant; TEL-TrkC fusion protein; Trk-C; trkC; TrkC tyrosine kinase; tyrosine kinase receptor C; unnamed protein product

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Gene Aliases: AW125844; gp145(trkC); GP145-TrkC; NTRK3; Ntrk3_tv3; TRKC

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UniProt ID: (Human) Q16288, (Mouse) Q6VNS1, (Rat) Q03351

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Entrez Gene ID: (Human) 4916, (Mouse) 18213, (Rat) 29613

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Function(s)
nucleotide binding p53 binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin receptor activity protein binding ATP binding kinase activity transferase activity neurotrophin binding transferase activity, transferring phosphorus-containing groups ephrin receptor binding transmembrane signal receptor
Process(es)
neuron migration cell communication transmembrane receptor protein tyrosine kinase signaling pathway nervous system development heart development circadian rhythm positive regulation of cell proliferation positive regulation of gene expression positive regulation of neuron projection development neuronal action potential propagation myelination in peripheral nervous system cell differentiation positive regulation of cell migration neurotrophin signaling pathway mechanoreceptor differentiation positive regulation of apoptotic process positive regulation of MAPK cascade response to ethanol ephrin receptor signaling pathway animal organ development neuron fate specification axon extension involved in regeneration response to axon injury positive regulation of axon extension involved in regeneration negative regulation of astrocyte differentiation system development positive regulation of positive chemotaxis response to corticosterone positive regulation of protein kinase B signaling positive regulation of synapse assembly lens fiber cell differentiation cellular response to retinoic acid cochlea development postsynaptic density assembly regulation of presynapse assembly cellular response to nerve growth factor stimulus regulation of neural precursor cell proliferation activation of MAPK activity negative regulation of protein phosphorylation protein phosphorylation multicellular organism development phosphorylation activation of protein kinase B activity positive regulation of peptidyl-serine phosphorylation protein autophosphorylation negative regulation of cell death activation of GTPase activity positive regulation of actin cytoskeleton reorganization peptidyl-tyrosine phosphorylation modulation by virus of host transcription
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