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Rockland
TrkCT1 Polyclonal Antibody
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FIGURE: 1 / 3
TrkCT1 Antibody (600-401-993) in WB
Mouse cortex lysate was immunoprecipitated with anti-TrkCT1 antibody and further blotted with affinity purified anti-TrkCT1. Lane 1 is wild-type cortex lysate, Lane 2 is Tamalin knock-out cortex lysate, and Lane 3 is TrkCT1 knock-out cortex lysate. The membrane was probed with the primary antibody at a 1:6,000 dilution. Personal Communication, V. Coppola, CCR-NCI, Frederick, MD.
Product Details
600-401-993
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the carboxyl terminus of mouse TrkCT1 protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
0.02M potassium phosphate, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
Directed against mouse TrkCT1 protein. A BLAST analysis was used to suggest cross-reactivity with TrkCT1 protein from human, mouse and rat based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.
Target Information
NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; neural receptor protein-tyrosine kinase (trkC); Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin-3; NT-3 growth factor receptor; Trk-C; TrkC tyrosine kinase; tyrosine kinase receptor C
Gene Aliases: AW125844; gp145(trkC); GP145-TrkC; NTRK3; Ntrk3_tv3; TRKC
UniProt ID: (Human) Q16288, (Mouse) Q6VNS1, (Rat) Q03351
Entrez Gene ID: (Human) 4916, (Mouse) 18213, (Rat) 29613
p53 binding
GPI-linked ephrin receptor activity
neurotrophin receptor activity
protein binding
ATP binding
neurotrophin binding
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
ephrin receptor binding
transmembrane signal receptor
activation of MAPK activity
neuron migration
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
heart development
circadian rhythm
positive regulation of cell proliferation
positive regulation of gene expression
peptidyl-tyrosine phosphorylation
modulation by virus of host transcription
positive regulation of cell migration
activation of protein kinase B activity
positive regulation of peptidyl-serine phosphorylation
neurotrophin signaling pathway
mechanoreceptor differentiation
positive regulation of apoptotic process
response to ethanol
protein autophosphorylation
ephrin receptor signaling pathway
neuron fate specification
response to axon injury
positive regulation of axon extension involved in regeneration
negative regulation of astrocyte differentiation
positive regulation of positive chemotaxis
response to corticosterone
positive regulation of synapse assembly
negative regulation of cell death
lens fiber cell differentiation
cellular response to retinoic acid
cochlea development
activation of GTPase activity
positive regulation of actin cytoskeleton reorganization
protein phosphorylation
multicellular organism development
nervous system development
phosphorylation
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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