Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene.
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Protein Aliases: hWRS; IFI 53; IFP 53; IFP53; Interferon-induced protein 53; T1-TrpRS; T2-TrpRS; TrpRS; tryptophan tRNA ligase 1, cytoplasmic; Tryptophan--tRNA ligase, cytoplasmic; Tryptophanyl-tRNA synthetase; tryptophanyl-tRNA synthetase, cytoplasmic; WARS protein
Gene Aliases: GAMMA-2; IFI53; IFP53; TrpRS; WARS; WRS