Immunogen sequence: IVGGYNCEEN SVPYQVSLNS GYHFCGGSLI NEQWVVSAGH CYKSRIQVRL GEHNIEVLEG NEQFINAAKI IRHPQYDRKT LNNDIMLIKL SSRAVINARV STISLPTAPP ATGTKCLISG WGNTASSGAD YPDELQCLDA PVLSQAKCEA SYPGKITSNM FCVGFLEGGK DSCQGDSGGP VVCNGQLQGV VSWGDGCAQK NKPGVYTKVY NYVKWIKNTI AANS; Positive Samples: HT-29, Mouse spleen, Mouse kidney; Cellular Location: extracellular space
Trypsin is a 24 kDa enzyme of the serine proteinase family. It is produced in the pancreas as an inactive precursor, trypsinogen, but the active enzyme is located in the gastrointestinal tract where it degrades proteins to large peptides. Trypsin prefers lysine and arginine residues. One of the substrates for trypsin is chymotrypsinogen which is cleaved to produce active chymotrypsin. High levels of immunoreactive trypsin in the bloodstream can indicate pancreatic malfunction and this indicator is used to screene for and diagnose Cystic Fibrosis.
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Protein Aliases: Alpha-trypsin chain 1; Alpha-trypsin chain 2; Anionic trypsin II; Anionic trypsin-2; Anionic trypsinogen; Beta-trypsin; Cationic trypsinogen; digestive zymogen; nonfunctional trypsin 1; Pretrypsinogen II; protease serine 2 preproprotein; protease, serine, 1; protease, serine, 1 (trypsin 1); protease, serine, 2; protease, serine, 2 (trypsin 2); Serine protease 1; Serine protease 2; TCR V beta 4.1; trypsin 1; trypsin 2; Trypsin I; Trypsin II; Trypsin-1; Trypsin-2; trypsinogen 1; trypsinogen 16; trypsinogen 2; trypsinogen 20; trypsinogen A
Gene Aliases: PRSS1; PRSS2; Ta; Tesp4; TRP1; Try-1; TRY1; TRY2; TRY4; TRY8; Trygn16; TRYP; TRYP1; TRYP2