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Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Twist1/Twist2 encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. Twist1/Twist2 is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism.
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Protein Aliases: B-HLH DNA binding protein; bHLHa38; bHLHa39; charlie chaplin; Class A basic helix-loop-helix protein 38; Class A basic helix-loop-helix protein 39; dermis expressed 1; Dermis-expressed protein 1; Dermo-1; dermo-1 protein; H-twist; M-twist; MGC117334; Pluridigite; polydactyly EMS; Skam10Jus; twist basic helix-loop-helix transcription factor 1; twist basic helix-loop-helix transcription factor 2; twist gene homolog 1; twist homolog 1; twist homolog 2; TWIST homolog of drosophila; twist-related bHLH protein Dermo1; Twist-related protein 1; Twist-related protein 2
AA960487; ACS3; AMS; BBRSAY; BHLHA38; BHLHA39; BPES2; BPES3; CRS; CRS1; CSO; DERMO1; FFDD3; M-Twist; Pde; pdt; SCS; SETLSS; Ska10; Ska
Molecular Function: basic helix-loop-helix transcription factor