PA5-28510 targets U2AF35 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-28510 immunogen is recombinant protein fragment corresponding to a region within amino acids 23 and 227 of Human U2AF35.
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This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Protein Aliases: 35-KD subunit; FP793; RN; RNU2AF1; splicing fac; Splicing factor U2AF 35 kDa subunit; Splicing factor U2AF 35 kDa subunit-like protein; splicing factor U2AF 35kDa subunit; U2 auxiliary factor 35 kDa subunit; U2 small nuclear ribonucleoprotein auxillary factor; U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit; U2 small nuclear RNA auxiliary factor 1; U2 small nuclear RNA auxiliary factor 1-like protein 5; U2 small nuclear RNA auxillary factor 1; U2 snRNP auxiliary factor small subunit; U2(RNU2) small nuclear RNA auxiliary factor binding protein; U2AF35; U2AFBP
Gene Aliases: FP793; RN; RNU2AF1; U2AF1; U2AF1L5; U2AF35; U2AFBP
UniProt ID: (Human) Q01081
Entrez Gene ID: (Human) 7307