This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
PA5-30442 targets U2AF65 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30442 immunogen is recombinant protein fragment corresponding to a region within amino acids 252 and 426 of Human U2AF65.
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U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.
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Protein Aliases: hU2AF(65); hU2AF65; splicing factor U2AF; splicing factor U2AF 65 kD subunit; Splicing factor U2AF 65 kDa subunit; U2 (RNU2) small nuclear RNA auxiliary factor 2; U2 auxiliary factor 65 kDa subunit; U2 small nuclear ribonucleoprotein auxiliary factor (65kD); U2 small nuclear ribonucleoprotein auxiliary factor (U2AF), 65 kDa; U2 snRNP auxiliary factor large subunit
Gene Aliases: 65kDa; U2AF2; U2AF65