This target displays homology in the following species: Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 83%
UAP1 is a 56KDa isoform which catalyzes the final step of UDP-N-acetylglucosamine (UDP-GlcNAc) biosynthesis from fructose-6-phosphate. UDP-GlcNAc, the activated form of GlcNAc moiety is used as a key precursor in N-linked glycosylation and the glycosylphosphatidylinositol (GPI)-anchor of cellular proteins. Crystallization studies revealed UAP1 is composed of a large central core flanked by two smaller extra domains. The central main domain displays a alpha/beta structure resembling the Rossmann fold. Northern Blot analysis detected abundant expression of UAP1 in testis and sperm with a low expression in placenta, muscle and liver. It is implicated in antibody-mediated infertility in males.
Protein Aliases: UAP1; UDP-N-acetylhexosamine pyrophosphorylase-like protein 1
Gene Aliases: 5730445F03Rik; Uap1l1
UniProt ID: (Mouse) Q3TW96
Entrez Gene ID: (Mouse) 227620