PA5-27427 targets UAP56 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-27427 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 304 of Human UAP56.
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This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and also plays an important role in mRNA export from the nucleus to the cytoplasm. A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants encoding the same protein have been described.
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Protein Aliases: 56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; BAT1; D6S81E; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; DEAD box protein UAP56; HLA-B-associated transcript 1 protein; nuclear RNA helicase (DEAD family); spliceosome RNA helicase BAT1; Spliceosome RNA helicase DDX39B; UAP56
Gene Aliases: BAT1; D6S81E; DDX39B; UAP56
UniProt ID: (Human) Q13838
Entrez Gene ID: (Human) 7919