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Invitrogen
UAP56 Polyclonal Antibody
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Product Details
PA5-97021
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 319-428 of human UAP56/UAP56/DDX39B (NP_0046311)
Conjugate
Form
Liquid
Concentration
1.5 mg/mL
Amount
150 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: RGMPQEERLS RYQQFKDFQR RILVATNLFG RGMDIERVNI AFNYDMPEDS DTYLHRVARA GRFGTKGLAI TFVSDENDAK ILNDVQDRFE VNISELPDEI DISSYIEQTR; Positive Samples: 293T, HeLa, LO2, SKOV3, K-562, SW620; Cellular Location: Cytoplasm, Nucleus, Nucleus speckle
Target Information
This gene encodes a member of the DEAD box family of RNA-dependent ATPases that mediate ATP hydrolysis during pre-mRNA splicing. The encoded protein is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and also plays an important role in mRNA export from the nucleus to the cytoplasm. A cluster of genes, BAT1-BAT5, is localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. Mutations in this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 56 kDa U2AF65-associated protein; ATP-dependent RNA helicase p47; D17H6S81E-1; D20H6S81e; DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B; DEAD box protein UAP56; DEAD-box helicase 39B; HLA-B associated transcript 1; HLA-B associated transcript 1A; HLA-B-associated transcript 1 protein; HLA-B-associated transcript 1A; Nuclear RNA helicase; nuclear RNA helicase (DEAD family); nuclear RNA helicase Bat1; spliceosome RNA helicase BAT1; Spliceosome RNA helicase DDX39B; unnamed protein product
Gene Aliases: 0610030D10Rik; AI428441; Bat-1; BAT1; Bat1a; D17H6S81E; D17H6S81E-1; D6S81E; D6S81Eh; DDX39B; p47; UAP56
UniProt ID: (Human) Q13838, (Rat) Q63413, (Mouse) Q9Z1N5
Entrez Gene ID: (Human) 7919, (Rat) 114612, (Mouse) 53817
nucleotide binding
nucleic acid binding
RNA binding
RNA helicase activity
mRNA binding
helicase activity
protein binding
ATP binding
RNA-dependent ATPase activity
hydrolase activity
ATPase activity
U6 snRNA binding
U4 snRNA binding
identical protein binding
ATP-dependent protein binding
ATP-dependent RNA helicase activity
poly(A) RNA binding
spliceosomal complex assembly
mRNA splicing, via spliceosome
mRNA export from nucleus
RNA splicing
RNA secondary structure unwinding
positive regulation of DNA-templated transcription, elongation
viral mRNA export from host cell nucleus
negative regulation of DNA damage checkpoint
mRNA processing
RNA export from nucleus
mRNA transport
transport
cellular response to DNA damage stimulus
regulation of gene expression
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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