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Proteintech
UBA6 Polyclonal Antibody
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Product Details
13211-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UBA6 Fusion Protein Ag4000 (87-389 aa encoded by BC031637)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes the full-length (118 kDa) and the truncated isoform CRA_b (60-70 kDa) of UBA6 (NCBI).
Immunogen sequence: AVTIHDTEK CQAWDLGTNF FLSEDDVVNK RNRAEAVLKH IAELNPYVHV TSSSVPFNET TDLSFLDKYQ CVVLTEMKLP LQKKINDFCR SQCPPIKFIS ADVHGIWSRL FCDFGDEFEV LDTTGEEPKE IFISNITQAN PGIVTCLENH PHKLETGQFL TFREINGMTG LNGSIQQITV ISPFSFSIGD TTELEPYLHG GIAVQVKTPK TVFFESLERQ LKHPKCLIVD FSNPEAPLEI HTAMLALDQF QEKYSRKPNV GCQQDSEELL KLATSISETL EEKVTIEIYG CPNICLLIHK CSVY (87-389 aa encoded by BC031637)
Target Information
UBA6 (UBE1L2, MOP-4) is a novel E1 enzyme specific for ubiquitin and belongs to the ubiquitin-activating E1 family. It is a part of the cascade to attach ubiquitin (Ub) covalently to substrate proteins. UBA6 activates ubiquitin by first adenylating its carboxy-terminal glycine residue with ATP and then linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Its isoforms influence spermatogenesis and male fertility. UBA6 is highly expressed in human monocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: E1-L2; Monocyte protein 4; MOP-4; UBA6; UBA6, ubiquitin-activating enzyme E1; Ubiquitin-activating enzyme 6; ubiquitin-activating enzyme E1-like 2; Ubiquitin-activating enzyme E1-like protein 2; Ubiquitin-like modifier-activating enzyme 6; unnamed protein product
Gene Aliases: 4930542H01; 5730469D23Rik; AU021846; AW124799; E1-L2; MOP-4; MOP4; UBA6; UBE1L2
UniProt ID: (Human) A0AVT1, (Mouse) Q8C7R4
Entrez Gene ID: (Human) 55236, (Mouse) 231380
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
protein ubiquitination
cellular protein modification process
learning
locomotory behavior
amygdala development
hippocampus development
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
dendritic spine development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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