Immunogen sequence: LHLSFLQNAA KLYATVYCIP FAEEDLSADA LLNILSEVKI QEFKPSNKVV QTDETARKPD HVPISSEDER NAIFQLEKAI LSNEAT
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 87%.
UBA6 (UBE1L2, MOP-4) is a novel E1 enzyme specific for ubiquitin and belongs to the ubiquitin-activating E1 family. It is a part of the cascade to attach ubiquitin (Ub) covalently to substrate proteins. UBA6 activates ubiquitin by first adenylating its carboxy-terminal glycine residue with ATP and then linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thioester and free AMP. Its isoforms influence spermatogenesis and male fertility. UBA6 is highly expressed in human monocytes.
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Protein Aliases: E1-L2; Monocyte protein 4; MOP-4; UBA6; UBA6, ubiquitin-activating enzyme E1; UBE1L2; Ubiquitin-activating enzyme 6; ubiquitin-activating enzyme E1; ubiquitin-activating enzyme E1-like 2; Ubiquitin-activating enzyme E1-like protein 2; ubiquitin-like modifier activating enzyme 6; Ubiquitin-like modifier-activating enzyme 6
Gene Aliases: 4930542H01; 5730469D23Rik; AU021846; AW124799; E1-L2; MOP-4; MOP4; RGD1308324; UBA6; UBE1L2