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UBE2A Polyclonal Antibody
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Product Details
BS-8375R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human UBE2A/RAD6, amino acids 81-152.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E2 ubiquitin-conjugating enzyme A; HHR6A (Human homologue of yeast RAD 6); putative; HR6A; RAD6 homolog A; Ubiquitin carrier protein A; Ubiquitin-conjugating enzyme E2 A; ubiquitin-conjugating enzyme E2A; ubiquitin-conjugating enzyme E2A (RAD6 homolog); ubiquitin-conjugating enzyme E2A, RAD6 homolog; ubiquitin-conjugating enzyme HR6A; Ubiquitin-protein ligase A; unnamed protein product
Gene Aliases: HHR6A; HR6A; Mhr6a; MRXS30; MRXSN; RAD6A; UBC2; UBE2A
UniProt ID: (Human) P49459, (Mouse) Q9Z255
Entrez Gene ID: (Human) 7319, (Rat) 298317, (Mouse) 22209
nucleotide binding
ubiquitin-protein transferase activity
protein binding
ATP binding
transferase activity
ubiquitin-like protein transferase activity
ubiquitin protein ligase binding
ubiquitin binding
ubiquitin conjugating enzyme activity
molecular_function
ligase activity
ubiquitin protein ligase activity
protein polyubiquitination
in utero embryonic development
DNA repair
biological_process
positive regulation of cell proliferation
response to UV
protein ubiquitination
histone ubiquitination
histone H2A ubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
protein autoubiquitination
maternal process involved in female pregnancy
protein K48-linked ubiquitination
protein K11-linked ubiquitination
G2/M transition of mitotic cell cycle
cytoplasmic translation
postreplication repair
chromatin organization
chromatin remodeling
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
positive regulation of mitophagy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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