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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
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Protein Aliases: (E3-independent) E2 ubiquitin-conjugating enzyme D3; E2 ubiquitin-conjugating enzyme D3; E2(17)KB 3; MGC43926; MGC5416; PAPase; Phosphoarginine phosphatase; PRO2116; Ubiquitin carrier protein D3; ubiquitin conjugating enzyme E2D 3; Ubiquitin-conjugating enzyme E2 D3; Ubiquitin-conjugating enzyme E2(17)KB 3; Ubiquitin-conjugating enzyme E2-17 kDa 3; ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5); ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast); Ubiquitin-protein ligase D3
Gene Aliases: 1100001F19Rik; 9430029A22Rik; AA414951; E2(17)KB3; UBC4/5; UBC5C; UBCH5C; UBE2D3
UniProt ID: (Human) P61077, (Mouse) P61079, (Rat) P61078
Entrez Gene ID: (Human) 7323, (Mouse) 66105, (Rat) 81920
Molecular Function:
ligase
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