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Proteintech
UBE2K Polyclonal Antibody
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Product Details
11834-3-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
UBE2K Fusion Protein Ag2415 (1-200 aa encoded by BC022804)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Amount
49.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MANIAVQRI KREFKEVLKS EETSKNQIKV DLVDENFTEL RGEIAGPPDT PYEGGRYQLE IKIPETYPFN PPKVRFITKI WHPNISSVTG AICLDILKDQ WAAAMTLRTV LLSLQALLAA AEPDDPQDAV VANQYKQNPE MFKQTARLWA HVYAGAPVSS PEYTKKIENL CAMGFDRNAV IVALSSKSWD VETATELLLS N (1-200 aa encoded by BC022804)
Target Information
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp564C1216; DKFZp686J24237; E2 ubiquitin-conjugating enzyme K; E2(25K); HIP-2; huntingtin interacting protein 2; Huntingtin-interacting protein 2; Ubiquitin carrier protein; ubiquitin conjugating enzyme E2K; Ubiquitin-conjugating enzyme E2 K; Ubiquitin-conjugating enzyme E2(25K); Ubiquitin-conjugating enzyme E2-25 kDa; ubiquitin-conjugating enzyme E2-25K; ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast); Ubiquitin-protein ligase; unnamed protein product
Gene Aliases: AW492011; D5Ertd601e; E2-25K; HIP2; HYPG; LIG; UBC1; UBE2K
UniProt ID: (Human) P61086, (Mouse) P61087
Entrez Gene ID: (Human) 3093, (Mouse) 53323, (Rat) 289623
nucleotide binding
ubiquitin-protein transferase activity
protein binding
ATP binding
transferase activity
ubiquitin protein ligase binding
ubiquitin-ubiquitin ligase activity
ubiquitin conjugating enzyme activity
ligase activity
ubiquitin protein ligase activity
ubiquitin-like protein transferase activity
ubiquitin-protein ligase
protein polyubiquitination
ubiquitin-dependent protein catabolic process
positive regulation of peptidyl-threonine phosphorylation
free ubiquitin chain polymerization
protein ubiquitination
regulation of proteasomal ubiquitin-dependent protein catabolic process
cellular response to interferon-beta
type I interferon signaling pathway
positive regulation of type I interferon-mediated signaling pathway
protein K48-linked ubiquitination
positive regulation of tumor necrosis factor-mediated signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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