FIGURE: 1 / 3
Immunogen sequence: AFNLRISFPP EYPFKPPMIK FTTKIYHPNV DENGQICLPI ISSENWKPCT KTCQVLEALN VLVNRPNIRE PLRMDLADLL TQNPELFRKN AEEFTLRFGV DRPS; Positive Samples: U-87MG, Jurkat, Mouse kidney, Mouse liver, Mouse lung, Mouse spleen, Rat kidney, Rat liver
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2L6 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to function in the E6/E6-ap-induced ubiquitination of p53.
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Protein Aliases: E2 ubiquitin conjugating enzyme; E2 ubiquitin-conjugating enzyme L6; MGC40331; retinoic acid induced gene B protein; Retinoic acid-induced gene B protein; RIG-B; UbcH8; UbcM8; Ubiquitin carrier protein L6; ubiquitin conjugating enzyme E2L 6; ubiquitin-conjugating enzyme 8; ubiquitin-conjugating enzyme E2L 6; Ubiquitin-protein ligase L6; Ubiquitin/ISG15-conjugating enzyme E2 L6
Gene Aliases: 2810489I21Rik; RIG-B; Ubce8; UBCH8; Ubcm8; UBE2L6
Molecular Function: ubiquitin-protein ligase